CV
Education
- B.S. in Physics, Universidad de los Andes, Colombia, 2016
- B.S. in Biology, Universidad de los Andes, Colombia, 2017
- M.S. in Biomedical Engineering, Cornell University, 2019
- Ph.D in Biomedical Engineering, Cornell University, 2022 (expected)
Work experience
- 2017-current, Graduate Student
- Cornell University, Ithaca, NY.
- Currently investigating the role of cerebral blood flow (CBF) deficits in the APP/PS1 mouse model of Alzheimer’s disease (AD) through in vivo multiphoton imaging.
- Supervisor: Chris Schaffer, PhD.
- Summer 2022: Consultant
- Genentech, San Francisco, CA.
- I’m continuing the work from the past summer in understanding the prognostic utility of tau PET and white matter hyperintensities for cognitive decline in mild and prodromal AD patients. In addition, I’m preparing a poster showcasing this work for the 2022 Alzheimer’s Association International Conference in San Diego, CA.
- Supervisor: Edmond Teng, MD, PhD.
- Summer 2021: Clinical Science Intern
- Genentech, San Francisco, CA.
- Explored the prognostic utility of tau PET for cognitive vs functional decline in mild to prodromal Alzheimer’s disease patients from the semorinemab phase-two clinical trials
- Supervisor: Edmond Teng, MD, PhD.
- Summer 2018: Research Intern
- Weill Cornell Medicine, New York, NY.
- Developed a magnetic imaging phantom and optimized a magnetic resonance imaging (MRI) sequence for imaging chest wall deformity in patients with breast tissue expanders. Assessed the amount of chest wall compression in more than 50 patients with expanders and implants. Trained to acquire images of phantoms and patients with a MRI machine.
- Supervisor: Martin Prince, MD, PhD.
- Summer 2016: Research Intern
- Laboratory of Neurophysiology and New Microscopies , Paris, France.
- Performed in vivo two-photon imaging of the mouse olfactory bulb under sensory stimuli and light stimulation in genetically modified and naive animals.
- Supervisor: Serge Charpak, PhD.
- Summer 2015: Research Intern
- Applied and Engineering Physics, Cornell University, Ithaca, NY.
- Performed in vivo three-photon microscopy to visualize neurons and calcium dynamics in hippocampal CA1 pyramidal neurons of the mouse brain
- Supervisor: Chris Xu, PhD.
- June 2013 - August 2016: Undergraduate Research Assistant
- Biophysics Lab, Universidad de los Andes, Bogota, Colombia
- Studied biomechanical properties of Trypanosoma cruzi flagellum under shear stress conditions
- Supervisors: Manu Forero-Shelton PhD and John Mario Gonzalez MD PhD
Publications
Muhammad Ali, Kaja Falkenhain, Brendah N Njiru, Muhammad Murtaza-Ali, Nancy E Ruiz-Uribe, Mohammad Haft-Javaherian, Stall Catchers, Nozomi Nishimura, Chris B. Schaffer, Oliver Bracko. VEGF signaling causes stalls in brain capillaries and reduces cerebral blood flow in Alzheimer’s mice (2022) Brain.
*Elizabeth Koman, *Emily Laurilliard, *Nancy E. Ruiz-Uribe, *Aziza Moore. Restoration Through Regeneration: A Scientific and Political Lens into Regenerative Agriculture in the United States. (2021) Journal of Science Policy and Governance. *Denotes equal contribution
Cristhian David Perdomo-Gomez, Nancy E. Ruiz-Uribe, John Mario Gonzalez, Antonio Manu Forero Shelton. Nanotubule formation in Trypanosoma cruzi under shear stress. (2021) In review Physical Biology
Nancy E. Ruiz-Uribe & Oliver Bracko. Brain and blood extraction for immunostaining, protein, and RNA measurements after long-term two photon imaging in mice. (2020) Protocol Exchange
Sung Ji Ahn, Nancy E. Ruiz-Uribe, Boqiang Li, Jason Porter, Sava Sakadzic, Chris B. Schaffer. Label-free measurement of blood flow speed in individual, cortical brain vessels using third harmonic generation microscopy (2020). Biomedical Optics Express. (This work was top downloaded in April 2020)
Oliver Bracko, Lindsay K. Vinarcsik, Jean C. Cruz Hernández, Nancy E. Ruiz-Uribe, Mohammad Haft-Javaherian, Kaja Falkenhain, Egle M. Ramanauskaite, Muhammad Ali, Aditi Mohapatra, Madisen A. Swallow, Brendah N. Njiru, Victorine Muse, Pietro E. Michelucci, Nozomi Nishimura, Chris B. Schaffer. High fat diet worsens pathology and impairment in an Alzheimer’s mouse model, but not by synergistically decreasing cerebral blood flow. (2020) Scientific Reports.
Kaja Falkenhain, Nancy E. Ruiz-Uribe, Mohammad Haft-Javaherian, Muhammad Ali, Stall Catchers contributors, Pietro E. Michelucci, Chris B. Schaffer, Oliver Bracko. Voluntary running does not increase capillary blood flow but promotes neurogenesis and short-term memory in the APP/PS1 mouse model of Alzheimer’s disease. (2020) PLOS ONE.
Talks and poster presentations
*Presenter at poster session at the 2022 Alzheimer’s Association International Conference (AAIC): “Prognostic utility of baseline [18F]GTP1 tau PET signal for subsequent cognitive and functional decline in prodromal-to-mild Alzheimer’s disease”. Nancy E. Ruiz-Uribe, Paul T. Manser, Brandon Butcher, Sandra Sanabria Bohorquez, Suzanne Baker, Cecilia Monteiro, Edmond Teng.
Presenter at poster session at the 2022 Gordon Conference in Optics and Photonics in Medicine and Biology. Nancy E. Ruiz-Uribe, Nathaniel H Allan-Rahill, Phillip Danziger, Argen Omurzakov, Madison Yang, Laura Berkowitz, Adina Mistry, Sylvie Lorthois, Nozomi Nishimura, Chris B. Schaffer. Long-duration, linescan measurement of microvascular dynamics of transient leukocyte passage in brain capillaries in the APP/PS1 mouse model of Alzheimer’s disease. Bates College, Lewiston, ME. July 10-15th 2022.
Panelist at the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) Journal Club: “Meet the Author”, where I presented the paper: “Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease” and hosted a Q&A session with the author: Dr. Cameron McAlpine. February 3rd, 2022.
Speaker at the 1st LatinX in BME symposium (virtual) organized by LatinX in BME and Florida International University (2021), with the talk: Neutrophil adhesion in brain capillaries contributes to cerebral blood flow deficits in APP/PS1 mice and is dependent on oxidative stress pathways. Nancy E. Ruiz-Uribe, Oliver Bracko, Madisen Swallow, Muhammad Ali, Brendah N. Njiru, Kaja Falkenhain, Hsin-Yun Chang, Costantino Iadecola, Laibaik Park, Nozomi Nishimura, and Chris B. Schaffer.
Speaker at webinar: Small and Mighty: Brain Capillaries in Health Disease (2021) with the talk: Neutrophil adhesion in brain capillaries contributes to cerebral blood flow deficits in APP/PS1 mice and is dependent on oxidative stress pathways. Nancy E. Ruiz-Uribe, Oliver Bracko, Madisen Swallow, Muhammad Ali, Brendah N. Njiru, Kaja Falkenhain, Hsin-Yun Chang, Costantino Iadecola, Laibaik Park, Nozomi Nishimura, and Chris B. Schaffer.
Presenter at poster session (changed to virtual conference due to COVID-19) at the 2020 Alzheimer’s Association International Conference (AAIC). Nancy E. Ruiz-Uribe, Oliver Bracko, Madisen Swallow, Muhammad Ali, Brendah N. Njiru, Kaja Falkenhain, Hsin-Yun Chang, Costantino Iadecola, Laibaik Park, Nozomi Nishimura, and Chris B. Schaffer. Neutrophil adhesion in brain capillaries contributes to cerebral blood flow deficits in APP/PS1 mice and is dependent on oxidative stress pathways. Amsterdam, The Netherlands, July 27th -31st, 2020.
Presenter at poster session at the Optical Society of America (OSA) Biophotonics 2019: Optics and the Brain. Ruiz-Uribe, N.E., Ahn, S.J., Schaffer, C.B. Label-free measurement of blood flow speed in individual, cortical brain vessels using third harmonic generation microscopy. Tucson, Arizona, USA. April 11th-April 14th, 2019.
Presenter at poster session at the 14th international conference of Alzheimer’s and Parkison’s diseases (ADPD) 2019. Nancy E. Ruiz-Uribe, Oliver Bracko, Madisen Swallow, Muhammad Ali, Nozomi Nishimura, and Chris B. Schaffer. Inhibition of NOX2 Reduces Capillary Stalling and Restores Cerebral Blood Flow in a Mouse Model of Alzheimer’s Disease. Lisbon, Portugal, March 26th to March 31st , 2019.
Presenter at poster session at the annual Society for Neuroscience (SfN) meeting. Ruiz-Uribe, N.E., Ahn, S.J., Schaffer, C.B. Label-free measurement of blood flow speed in individual, cortical brain vessels using third harmonic generation microscopy. San Diego, CA, USA. November 4th-November 7th, 2018.
Presenter at poster session at the 61st annual Biophysical Society meeting. Ruiz-Uribe, N.E., Gonzalez J.M., and Forero-Shelton A.M., Mechanical Properties of Trypanosoma Cruzi Flagellum. New Orleans, Louisiana, USA. February 11th – February 15th, 2017.
Speaker at conference: ‘Investigar en pregrado sí se puede’ with the project: ‘Larval development and calcification processes in Pterogorgia guadalupensis under conditions of ocean acidification.’ Vicerrectoría de investigaciones. Universidad de los Andes. Bogotá, Colombia. May 2016
Speaker at Workshop: ‘Image Analysis: FIJI and MATLAB’. Department of Biological Sciences. Universidad de los Andes. Bogotá, Colombia. October 2015
Awards and Scholarships
2022
2021-2023
- American Heart Association Pre-Doctoral Fellowship
2020
- Alzheimer’s Association Vascular Cognitive Disorders PIA: 3MT Award
- Cornell Neurotech Mong Junior Fellowship
2019
- Registration waiver award for OSA Biophotonics 2019: Optics and the Brain
2018
- Fischell Graduate Scholarship in Bioengineering
- Cornell Graduate School Conference Travel grant award
- S. Arthur and Dorothy Neufeld Foundation Alzheimer Research Endowment Scholarship
2017
- Neufeld S. Arthur & Dorothy R. Scholarship
2015
- Summer Scholarship for Undergraduate Research – Cornell University - Uniandes